Bortenat 2mg | Bortenat 2mg Injection | Bortenat 2mg Injection Price in India
BORTENAT 2MG
DESCRIPTION
Bortezomib is sold under the brand name Bortenat 2mg which is a type of anti-cancer medicine, which is in the form of lyophilized powder A first beneficial proteasome inhibitor is known as Bortenat 2mg Injection ; proteasome is a cellular structure which breaks the proteins.
Bortenat 2mg injection will helps to prevent from multiple myeloma in patients with or without before treatment history and mantle cell lymphoma.
INDICATION
Multiple myeloma Bortenat 2mg is indicated to treat the patients suffering from multiple myeloma. Mantle cell lymphoma Bortenat 2mg Injection is indicated to treat the disease mantle cell lymphoma which the patients have received at least 1 prior therapy.
MECHANISM OF ACTION
Bortenat 2mg injection used in mammalian cells is a reversible inhibitor of the chymotrypsin-like activity of the 26-S proteasome. The drug prohibits targeted proteolysis that affects multiple signaling cascades responsible for normal homeostatic functions within the cell, leading to cell death.
PRODUCT DETAILS
Brand : Bortenat
Ingredients : Bortezomib
Strength : 2mg vial
Manufactured : Natco
Package : 2mg Bortezomib containing vial in a carton
ADME PROPERTIES
ABSORPTION
The peak plasma concentration after 1st dose is 57 and 112ng/mL, If administrated two times a week, Cmax observed for 1mg/m2dose is 67 to 106ng/mL, for 1.3mg/m2 is 89 to 720ng/mL.
DISTRIBUTION
Human serum plasma concentration is >80%
METABOLISM
Bortenat 2mg injection metabolized mainly through cytochrome P450 isoenzymes CYP3A4, CYP2C19 & CYP1A2.
ELIMINATION
The excretion pathways of Bortenat 2mg have not been characterized. The terminal elimination of half life after the 1mg/m2 dose is 40hrs – 193hrs, after dose 1.3mg/m2 is 76hrs – 108hrs.
DOSAGE MANAGEMENT
BORTENAT 2MG DOSAGE AND ADMINISTRATION
Bortenat 2mg is administrated alone or combination with dexamethasone Three week course is considered as therapy cycle Atleast 72 hours must slip away between constant doses of Bortenat. Bortenat 2mg Injection (lyophilized powder form) is reconstituted by using 0.9% sodium chloride (NS)Bortenat should be reconstituted in 3.5ml NS The route of administration is IV bolus Intrathecal not use for administration In adults:MANTLE CELL LYMPHOMA
The Bortenat 2mg recommended dose for untreated mantle cell lymphoma is;1.3mg/m2 of Bortenat administered as IV bolus given as two times weekly by combining with rituximab, cyclophospahmide, doxorubicin and tablet prednisolone for two weeks (day I, IV, VIII & XI) followed rest period of 10 days (day II through 21). In Relapse stage: The normal dose of Bortenat is 1.3mg/m2 administered as IV bolus or subcutaneous two times for two weeks (day I, IV, VIII & XI) followed by 10 day rest period (day II through 21) The therapy should followed for above 8 cycles may be given for once weekly for 4 weeks (day 1, 8, 15 & 22), followed by 13 day rest (days 23 through 35)
MULTIPLE MYELOMA
In the therapy of previously untreated multiple myeloma:1.3mg/m2 of dose must be given as 3 to 5 seconds through IV bolus or subcutaneous by concomitant use with tablet melphalan and prednisolone for nine 6 weeks therapy cycles Cycles 1 over 4, Bortenat 2mg Injection is administrated for two times weekly, (day 1, 4, 8, 11, 22, 25, 29 and 32) Cycles 5 over 9, Bortenat is administrated once a week (day 1, 8, 22, and 29)KEY POINTS
Moderately, 72 hours should be passing between following doses of Bortenat 2mgIN RELAPSE STAGE
The usual dose of Bortenat 2mg is 1.3mg/m2 should be administered through IV bolus or subcutaneous as two times for two weeks (day1, 4, 8, and 11) continued by a ten day of rest course (day 12 through 21)
PRECAUTION
While taking Bortenat 2mg some adverse effects occurs care should be taken in the conditions like Bortenat 2mg injection leads to peripheral neuropathy like burning sensation, hyperesthesia, hypoesthesia, paresthesia, -stop the Bortenat 2mg therapy Gastrointestinal toxicity-fluid or electrolyte replacements have to take Thrombocytopenia and neutropenia Tumor lysis syndrome Hepatic toxicity Embryo fetal toxicity
SIDE EFFECTS
BORTENAT 2MG SIDE EFFECTS
MOST COMMON SIDE EFFECTS
Black tarry stools ; Bleeding gums ; Blood in urine ; Blurred vision ; Body aches ; Burning, crawling, itching, numbness, prickling ;Chest pain ; Cough producing mucus, dizziness, faintness, nerve pain, painful urination, pale skin, runny nose, sore throat, stuffy nose, swollen glands, sunken eyes, ulcer, dry mouth, ear congestion, loss of voice
PREGNANCY & LACTATION:
Bortenat 2mg is not recommended in pregnancy condition, it causes harm to fetus Breast feeding is not recommended.
STORAGE :
Bortenat 2mg vial should be stored at 20°C to 25°C (68°F to 77°F) excursion between 15°C to 30°C (59°F to 86°F). Keep away from light and heat.
MISSED DOSE:
If a single dose missed then administer the dose as you remember, If it is near to next dose then skip the missed dose and follow the regular schedule. Bortenat 2mg Do not take extra dose at a time. Consult with the doctor for further changes in dose.
CONTACTS DETAILS
Email : millionhealthpharmaceuticals@gmail.com
Phone Number : +91-9940472902
Webiste : https://millionpharma.com/bortenat-2mg.php
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